University of Taipei:Item 987654321/2696
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    题名: Maximum number of live births per donor in artificial insemination
    作者: Charlotte Wang
    Miao-Yu Tsai
    Mei-Hsien Lee
    Su-Yun Huang
    Chen-Hung Kao
    Hong-Nerng Ho
    Chuhsing Kate Hsiao
    李美賢
    蔡秒玉
    黃素雲
    何弘能
    蕭朱杏
    贡献者: 臺北市立教育大學數學資訊教育學系
    关键词: artificial insemination by donor
    assortative mating
    coefficient of inbreeding
    consanguinity
    hereditary disease
    日期: 2007
    上传时间: 2009-08-04 10:54:21 (UTC+8)
    摘要: BACKGROUND: The maximal number of live births (k) per donor was usually determined by cultural and social perspective. It was rarely decided on the basis of scientific evidence or discussed from mathematical or probabilistic viewpoint.

    METHODS AND RESULTS: To recommend a value for k, we propose three criteria to evaluate its impact on consanguinity and disease incidence due to artificial insemination by donor (AID). The first approach considers the optimization of k under the criterion of fixed tolerable number of consanguineous mating due to AID. The second approach optimizes k under fixed allowable average coefficient of inbreeding. This approach is particularly helpful when assessing the impact on the public, is of interest. The third criterion considers specific inheritance diseases. This approach is useful when evaluating the individual's risk of genetic diseases. When different diseases are considered, this criterion can be easily adopted. All these derivations are based on the assumption of shortage of gamete donors due to great demand and insufficient supply.

    CONCLUSIONS: Our results indicate that strong degree of assortative mating, small population size and insufficient supply in gamete donors will lead to greater risk of consanguinity. Recommendations under other settings are also tabulated for reference. A web site for calculating the limit for live births per donor is available.
    關聯: HUMAN REPRODUCTION, V22(5), p.1363-1372
    显示于类别:[數學系(含數學教育碩士班)] 期刊論文

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